The effect of biostimulants on the biological development of karakul sheep

Currently, one of the major obstacles to ensuring the global population with environmentally friendly and high-quality livestock products, as well as food security, is the wide range of animal pathologies. Additionally, a decline in natural resistance, productivity, and fertility of animals, as well as growth and development retardation in young stock, leads to significant economic losses in agricultural enterprises.

To effectively address these problems, there is a growing need for modernization and intensive development of the production of local, environmentally safe veterinary drugs, particularly biopreparations capable of replacing imported analogs.

Biostimulant drugs exert a complex effect on the animal organism, stimulating metabolism, restoring central nervous system functions, and possessing immunobiological properties that promote tissue regeneration and increase resistance to pathogenic factors.

In global veterinary practice, large-scale scientific research is being conducted on the development of biostimulants, studying their pharmacological effects on animal organisms, and assessing the suitability of products in terms of veterinary and sanitary requirements.

Biostimulants are widely used to accelerate the growth and development of young stock, as well as to increase animal productivity. Modern research focuses particularly on preventing various infectious and non-infectious animal pathologies and diseases related to the immune system.

Object and Methodology of Research

The research was conducted in the vivarium of the Samarkand State University of Veterinary Medicine, Animal Husbandry, and Biotechnology. The experiment involved 12 Karakul lambs aged 3-4 months, which were divided into four groups of three individuals each.

The first, second, and third groups were experimental, while the fourth was the control group. Before the experiment, the lambs’ physiological parameters (respiratory rate, heart rate, body mass) were measured and recorded. The live weight of the lambs was determined every 15 days by weighing them on electronic scales.

Results and Analysis

The study involved 12 Karakul lambs aged 3-4 months, divided into four groups of three heads each.

• The first experimental group received “Preparation No.1,” administered intramuscularly at 3 ml every 10 days.

• The second experimental group received “Miosta H®” by “Miosta Group®,” administered intramuscularly at 2 ml once a month.

• The third experimental group received “Preparation No.3,” administered intramuscularly at 0.4 ml every 10 days.

• The fourth (control) group did not receive any drugs, but all groups were fed according to the standard farm diet.

To determine the pharmacological effect of the drugs on the lambs, body temperature, respiratory rate, and heart rate were measured, and their growth and development were monitored.

Physiological Indicators in the Control Group At the beginning of the experiment, the body temperature of the lambs was 39.5±0.04°C, which decreased to 39.3±0.02°C by the end. The heart rate (HR) decreased from 139.5±5.5 to 135.3±4.6 beats per minute, while the respiratory rate decreased from 60.5±2.6 to 58.7±2.5 breaths per minute.

First Experimental Group (“Preparation No.1”)

• Body temperature decreased from 39.4±0.04°C to 38.7±0.02°C.

• HR decreased from 140.5±4.5 to 130.5±3.6 beats per minute.

• Respiratory rate decreased from 61.2±2.6 to 56.2±2.5 breaths per minute.

Second Experimental Group (“Miosta H®”)

• Body temperature decreased from 39.6±0.04°C to 38.9±0.02°C.

• HR decreased from 140.5±4.5 to 132.7±3.7 beats per minute.

• Respiratory rate decreased from 60.6±2.6 to 58.7±2.5 breaths per minute.

Third Experimental Group (“Preparation No.3”)

• Body temperature decreased from 39.4±0.03°C to 39.1±0.03°C.

• HR decreased from 140.5±3.6 to 134.2±3.8 beats per minute.

• Respiratory rate decreased from 60.6±2.6 to 57.7±2.5 breaths per minute.

Live Weight Dynamics of Lambs Data analysis showed that:

• Lambs in the first group (“Preparation No.1”) gained 6.99% more weight compared to the control group.

• Lambs in the second group (“Miosta H®”) gained 10.15% more weight.

• Lambs in the third group (“Preparation No.3”) gained 5.45% more weight.

Thus, the best results were shown by the second group (“Miosta H®”).

Table 1 Clinical indicators of Karakul lambs (n=12)

Table 2 Dynamics of average live weight of lambs, kg

Conclusions

• The use of “Miosta H®” administered intramuscularly at 2 ml once a month has a positive effect on the growth and development of Karakul lambs.

• “Preparation No.1,” “Miosta H®,” and “Preparation No.3” in the first, second, and third experimental groups significantly improved the growth and development of lambs compared to the control group, ensuring a body mass increase after 60 days by 6.99%, 10.15%, and 5.45%, respectively.

• The best effect was recorded in the second group (“Miosta H®”).

References

• Khalikov A. A. et al. Effects of eleovit and megavit drugs on growth and development of calves //Galaxy International Interdisciplinary Research Journal. – 2022. – Vol. 10. – No. 3. – P. 1-3.

• Azamovich K. A. et al. Efficacy Of Tissue Products In Karakul Lambs, When Shown By Different Nutrition //European Journal of Agricultural and Rural Education. – 2021. – Vol. 2. – No. 6. – P. 40-42.

• Sharipov B.Q., Hayitov E.Sh., Boboqulov N.A. et al. Technological processes in Karakul breeding. Samarkand, 2021.

• Aliyev D.D. Physiological aspects of increasing the productivity of Surkhandarya Karakul sheep. Dissertation. Samarkand, 2021.

• Online source: Karakul sheep breed – Wikipedia (wikipedia.org)